CROSSLINKED DE TRAN MICROSPHERES (CDMS) WERE PREPARED BY CROSSLINKING OF THE P LYMER DISSOLVED IN INTERNAL PHASE OF AN INVERSE SUSPENSION SYSTEM USING EPICHLOROHYDRIN (ECH). TRACING Particle SIZE AND Particle SIZE distribution (PSD) OF CDMS DURING THE FABRICATION PROCESS IS IMPORTANT DUE TO THEIR DETERMINANT EFFECT ON DYNAMIC SWELLING PROPERTIES OF THE RESULTING ParticleS AS IMPORTANT CHARACTERISTICS FFECTING THEIR APPLICATION AS HEMOSTATIC AGENTS. TO THIS END, MAKING THE FABRICATION PROCESS CONTROLLABLE TO OBTAIN MICROSPHERES OF TUNABLE MEAN Particle SIZE AND PSD WAS THE MAJOR OBJECTIVE OF THIS STUDY. ACCORDING TO THE RESULTS, FOUR CHARACTERISTIC INTERVALS IN THE EVOLUTION OF Particle SIZE WERE IDENTIFIED AS TRANSITION, QUASI-STEADY-STATE, GROWTH, AND IDENTIFICATION STAGES LIKE ANY TYPICAL SUSPENSION POLYMERIZATION. IN TRANSITION STAGE, PSD NARROWED DRAMATICALLY AND DROPLET SIZE DECREASED EXPONENTIALLY DUE TO HIGHER RATE OF DROPLET BREAK-UP IN COMPARISON TO THE DROPLET COALESCENCE UNTIL A STEADY STATE WAS REACHED. THE MECHANISMS UNDERLYING THE GROWTH STAGE ARE EXPLAINED IN TERMS OF THE OVERALL RATES OF DROPLET BREAK-UP AND COALESCENCE IN THE COURSE OF POLYMERIZATION REACTION. THE GROWTH STAGE OCCURS IF DROPLETS ARE NOT SUFFICIENTLY STABLE AGAINST BOTH BREAK-UP AND COALESCENCE. THE ONSET OF THE GROWTH STAGE IS ADVANCED WITH A DECREASE IN THE RATE OF DROPLET BREAK-UP.